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課程資訊

課程名稱	毒理基因體學 TOXICOGENOMICS
開課學期	97-2
授課對象	公共衛生學院環境衛生研究所
授課教師	林靖愉
課號	EH5018
課程識別碼	844EU1260
班次
學分	2
全/半年	半年
必/選修	選修
上課時間	星期三3,4(10:20~12:10)
上課地點	公衛207
備註	本課程以英語授課。總人數上限：15人
Ceiba 課程網頁	http://ceiba.ntu.edu.tw/972toxicogenomics
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課程概述	This is an elective course for students interested in toxicogenomics. Application of genomic technologies, i.e. genomics, transcriptomics, proteomics, and metabolomics will be introduced. Genomic technologies will be first discussed. The course will then focus on application of genomic approaches to study the adverse effects of environmental stressors on health of human and environment at gene, protein, and metabolite level. The class is offered in English.
課程目標	To learn the technologies in toxicogenomics and be able to choose techniques to conduct toxicological studies.
課程要求	There will be a mid-term and a final examination. A term- paper and oral presentation are also required. The class is offered in English.
預期每週課後學習時數
Office Hours
指定閱讀
參考書目	Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment, National Academies Press, 2007
評量方式 (僅供參考)

課程進度

週次	日期	單元主題
Week 1	2/18	Introduction –toxicology
Week 2	2/25	Introduction –genomics
Week 3	3/4	Toxicogenomic technologies— (1) genomics
Week 4	3/11	Toxicogenomic technologies— (2) transcriptomics
Week 5	3/18	Toxicogenomic technologies— (3) proteomics
Week 6	3/25	Toxicogenomic technologies— (4) metabolomics
Week 7	4/1	Limitation and challenges of toxicogenomic techniques
Week 8	4/8	Filed trip—Genomics lab
Week 9	4/15	Midterm
Week 10	4/22	Experimental design and data analysis
Week 11	4/29	Application to exposure assessment
Week 12	5/6	Application to hazard screening
Week 13	5/13	Application to analyzing variation in human susceptibility
Week 14	5/20	Application to the study of mechanisms of action
Week 15	5/27	Student presentation
Week 16	6/3	Student presentation
Week 17	6/10	Review section
Week 18	6/17	Final exam